Seyyed Abolghasem Ghadami , Faculty Member of Alzahra University

Publications 

 1- S A Ghadami, F Bemporad, B Maria Sala, G Tiana, S Ricagno, F Chiti, FRET studies of various conformational states adopted by transthyretin. Cellular and Molecular life science (2017), 74(19), 3577–3598.

 

 2- S A Ghadami, R Khodarahmi, S Ghobadi, M Ghasemi and S Pirmoradi (2011) Amyloid fibril formation by native and modified bovine β-lactoglobulins proceeds through unfolded form of proteins: A comparative study, Biophys. Chem., 159: 313-320.

 

 3- S A Ghadami, Z Hossein-pour, R Khodarahmi, S Ghobadi and H Adibi (2013) Synthesis and in vitro characterization of some benzothiazole- and benzofuranone-derivatives for quantification of fibrillar aggregates and inhibition of amyloid-mediated peroxidase activity, Med. Chem. Res., 22: 115-126.

 

 4- S Conti, X Li, S Gianni, S A Ghadami, J N Buxbaum, C Cecchi, F Chiti and F Bemporad (2014) A Complex Equilibrium among Partially Unfolded Conformations in Monomeric Transthyretin, Biochemistry, 53: 4381-4392.

 

 5- R Khodarahmi, S A Karimi, M R Ashrafi, SA Ghadami, S Ghobadi and M Amani (2012) Comparative Spectroscopic Studies on Drug Binding Characteristics and Protein Surface Hydrophobicity of Native and Modified forms of Bovine Serum Albumin: Possible Relevance to Change in Protein Structure/Function upon non-Enzymatic Glycation, Spectrochimica Acta Part A, 89: 177-186.

 

 6- R Khodarahmi, Z Hossein-pour, S Ghobadi, K Mansouri, A Mostafaie, K Yari, S A Ghadami (2012) Non-specific peroxidase activity and catalase-inhibitory behavior of fibrillar aggregates after interaction with heme: relevance to the etiology of amyloid-related neurodegenerative disorders using the experimental-based evidences, J. Iran Chem. Soc., 9: 939-950.

 

 7- M Rostamian, S J Mousavy, F Ebrahimi, S A Ghadami, N Sheibani, M E Minaei, A Torabi, M Ali, (2012) Comparative Study of Immunological and Structural Properties of Two Recombinant Vaccine Candidates against Botulinum Neurotoxin Type E, Iranian Biomed. J. 16: 185-192.

 

 8- H Mahdiuni, N Bijari, M Varzandian, S A Ghadami, M Khazaei, M R Nikbakht, R Khodarahmi (2013) Appraisal of Sildenafil Binding on the Structure and Promiscuous Esterase Activity of Native and Histidine-Modified Forms of Carbonic Anhydrase II, Biophys. Chem., 17: 1-16.

 

 9- K Mansouri, R Khodarahmi, S A Ghadami(2013) An in vitro model for spontaneous angiogenesis using rat mesenteric endothelial cells: Possible therapeutic perspective for obesity and related disorders, Pharm. Biol., 51: 974-980.

 

 10- S Maghsoudi, M R Ashrafi-Kooshk, M Shahlaei, S A Ghadami, S Ghobadi, A Mostafaie, R Khodarahmi (2013) Comparative evaluation of amphotericin B binding to the native and modified forms of rice lipid-transfer protein: a possible perspective on improving the drug-binding affinity and specificity, J. Iran Chem. Soc., 10: 937-950.

 

 11-  M M Nadi, M R Ashrafi Kooshk, K Mansouri, S A Ghadami, M Amani, S Ghobadi, R Khodarahmi (2015) Comparative spectroscopic studies on Curcumin Stabilization by Association to Bovine Serum Albumin and Casein: A perspective on drug-delivery application. Int. J. Food Prop. 18: 638–659.

 

 12-  N Bijari, S Ghobadi, H Mahdiuni, R Khodarahmi, S A Ghadami (2015), Spectroscopic and molecular modeling studies on binding of dorzolamide to bovine and human carbonic anhydrase II, Int. J. Biol. Macromol., 80: 189-199.

 13- R Khodarahmi, M R Ashrafi-Kooshk, S Khodarahmi, S A Ghadami, A Mostafaie (2015).  Possible peroxidase active site environment in amyloidogenic proteins: Native monomer or misfolded-oligomer; which one is susceptible to the enzymatic activity, with contribution of heme? Int. J. Biol. Macromol., 80: 293-301

 14- R Khodarahmi, Z Hossein-pour, K Mansouri, S A Ghadami, (2015) Amyloidogenic Proteins, in Their Fibrillar States, May Be Detrimental Via Different Mechanisms: Perspective of Po-Tential Curative/Preventive Strategies Against Neurodege-Nerative Disorders, J. Rep. Pharm. Sci., 1: 27-40.

 15- M E Zare, R Khodarahmi, S A Ghadami, A N Kansestani, (2012) Challenge in cancer therapy with VAP-1 inhibition strategy: possible interference of this type of intervention within protection from autoimmunity: Hypothesis, J. Rep. Pharm. Sci.,1: 127-131.

 16- A Jangholi, M R Ashrafi-Kooshk, S S Arab, S Karima, M Poorebrahim, S A Ghadami, A A Moosavi-Movahedi, R Khodarahmi, (2018) Can any “non-specific charge modification within microtubule binding domains of Tau” be a prerequisite of the protein amyloidaggregation? An in vitro study on the 1N4R isoform, International Journal of Biological Macromolecules, 109, 188-204.

 17- D Jazaj, S A Ghadami, F Bemporad, F Chiti (2019) Probing conformational changes of monomeric transthyretin with second derivative fluorescence, Scientific reports 9 (1), 10988

 18- S Abbasbeigi, H Adibi, S Moradi, SA Ghadami*, R Khodarahmi (2019) Detection/quantification of amyloid aggregation in solution using the novel fluorescent benzofuranone-derivative compounds as amyloid fluorescent probes: synthesis and in vitro characterization, , Journal of the Iranian Chemical Society 16 (6), 1225-1237.

 

Seminars and Conferences


[1] Conti,X.Li, S. Gianni, S. A. Ghadami, J. Buxbaum, C. Cecchi, F. Chiti,F. Bemporad, Investigating partially unfolded conformations populated by monomeric human transthyretin, FEBS Journal, 282, (Suppl. 1) (2015) 56–408.

 

[2] Seyyed Abolghasem Ghadami, Francesco Bemporad, Fabrizio Chiti, Study of the conformational changes occurring in human transthyretin that are necessary for amyloid fibril formation in disease and for its role as a detoxifier, The XV International Symposium on Amyloidosis, Uppsala, 3-7 July, 2016.

 

[3] Seyyed Abolghasem Ghadami, F. Tramontana, S. Conti, C. Cecchi, Fabrizio Chiti, Francesco Bemporad, Investigating partially unfolded poorly populated conformations of human transthyretin, The XV International Symposium on Amyloidosis, Uppsala, 3-7 July, 2016.

 

[4] Seyyed Abolghasem Ghadami, Moosa Ghasemi, Reza khodarahmi, Sirous Ghobadi, Comparative study on the formation of amyloid fibrils in the native and modified β-lactoglobulins, 11th Iranian Congress of Biochemistry and Molecular Biology, Qazvin University of Medical Sciences, 7-9 Feb 2011, Qazvin, Iran.

 

[5] Reza Khodarahmi, S.Arash Karimi, Mohammad Reza Ashrafi, Seyyed Abolghasem Ghadami, Sirous Ghobadi, Mojtaba Amani, Comparative Studies on PSH, Drug Binding Characteristics and Conformational Stability of Native and Modified Forms of Bovine Serum Albumin, International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.

 

[6] Reza Khodarahmi, S.Arash Karimi, Mohammad Reza Ashrafi, Seyyed Abolghasem Ghadami, Sirous Ghobadi, Mojtaba Amani, Comparative Studies on Drug Binding Characteristics and Protein Surface Hydrophobicity of Native and Modified forms of Bovine Serum Albumin: Possible Relevance to Change in Protein Structure Upon Glycation, The First International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.

 

[7] Reza Khodarahmi, Zahra Hosseinpour, Sirous Ghobadi, Kamran Mansouri, Ali Mostafaie, Khirollah Yari, Seyyed Abolghasem Ghadami, Fibrillar, Protein Aggregation May be Detrimental Via Different Oxidative Routes: Relevance to the Etiology of Amyloid-Related Neurodegenerative Disorders Using the Experimental-Based Evidences, The First International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.

 

[8] Reza Khodarahmi, Seyyed Abolghasem Ghadami, Sirous Ghobadi, Prediction of Aggregation Propensity and Amyloidogenic Regions in Proteins, Based on Their Primary Sequences, The First International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.

 

[9] Reza Khodarahmi, Shabnam Maghsoudi, Mohammad Reza Ashrafi, Seyyed Abolghasem Ghadami, Sirous Ghobadi, Marzieh Hamzeh, Purification of Lipid-Transfer Protein-1 (LTP-1) from Rice Grain and Study of Drug Binding to Normal and Modified LTPs, The First International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.

 

[10] Reza Khodarahmi, Nooshin Bijari, Seyyed Abolghasem Ghadami, Sirous Ghobadi, Comparative Evaluation of Sildenafil Effects on the Structure and Activity of Native and Modified States of Human Carbonic Anhydrase II, The First International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.

 

[11] Seyyed Abolghasem Ghadami, Reza Khodarahmi, Hadi Adibi, Sirous Ghobadi, Detection of Fibrillar Aggregates and Inhibition of Amyloid-Mediated Peroxidase Activity Using the Novel Benzothiazoleand Benzofuranone-Derivatives Fluorescence Compounds, The First International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.

 

[12] Sirous Ghobadi, Reza Khodarahmi, Mona Pazhohi, Seyyed Abolghasem Ghadami, Noushin Bijari, Investigation on the Effects of Glibenclamide on the Structure and Function of Human Carbonic Anhydrase ІІ, The First International & 11th Iran Biophysical Chemistry Conference, 13-15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.


[13] Seyyed Abolghasem Ghadami, Fabrizio Chiti, Francesco Bemporad, Analysis of Transthyretin partially folded states by FRET, Advances in Biophysical Methods for Protein Characterisations Conference, 4-6 October 2016, Palermo, Italy (talk)


[14] Seyyed Abolghasem Ghadami, Fabrizio Chiti, Francesco Bemporad, Analysis of conformational changes in native and mutants human transthyretin during the folding and aggregation processes, Conference of Biophysical Chemistry, 23-24October 2018, Gorgan, Iran (talk)

 

Workshops

1-    Endnote workshop teaching, 1388 

2-    Scientific search on net workshop workshop, 1388

3-    Research tools, Course, Royan Institute, 1397

4-    Endnote and Zotero software workshop teaching, 1396

5-    Image J software workshop teaching, 1397

6-    Image processing in science workshop teaching, 1397